Informatics Publishing Limited

N. S. Dighe ¹, S. R. Pattan ¹, S. B . Dighe ¹, S. B. Bhawar ¹, R. B. Saudagar ², V. M. Gaware ¹, M. B. Hole ¹, V. B. Tambe ¹

Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, IN
2 R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, IN

Abstract

Chikungunya virus is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. The virus causes an illness with symptoms similar to dengue fever with an acute febrile phase of the illness which lasts only two to five days. Infection can affect the nervous system or the musculo-skeletal system. General symptoms include fever, headache, maculopapular rash, arthralgia, myalgia, photophobia and lymphadenopathy. Virus isolation provides the most definitive diagnosis. The most effective means of prevention are protection against contact with the disease-carrying mosquitoes and mosquito control. NSAIDs, chloroquine and DNA vaccine are the effective medicines.

Keywords

Chikungunya, Aedes Mosquitoes, Fever, Chloroquine.

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S. B. Datir ¹, S. A. Nirmal ², A. B. Ganjare ², S. B. Bhawar ³, M. J. Patil ⁴

Affiliations
1 Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, A/P- Loni, Tal -Rahata, Dist- Ahmednagar, Pin- 413736, Maharashtra, IN
2 Dep. of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, IN
3 Dep. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, IN
4 Deparrment of Pharmacognosy, M.M. College of Pharmacy, Pune, IN

Abstract

Achyranthes aspera is common weed found in India and has great medicinal importance. The plant is beneficial in various ailments including stomachache, piles, boils, skin eruption and in asthma. It is also used as anti-inflammatory and as immunomodulator drug. It may act on reactive oxygen species which are one of the factor in the pathogenesis of these diseases. Various extracts of A. aspera, viz., petroleum ether extract, chloroform extract, ethyl acetate extract, ethanol extract and aqueous extract were screened for the antioxidant activity of the plant by using DPPH assay, ABTS assay and FRAP assay. Among all these extracts petroleum ether extract was found to be active as it shows lowest IC50 value in DPPH assay and highest trolox equivalent antioxidant concentration (TEAC) in ABTS assay and FRAP assay. Phytochemical screening revealed that as flavonoids, tannins and phenolic compound are absent in the plant, nonpolar compounds like steroids may be responsible for the antioxidant activity of the plant.

Keywords

Achyranthes aspera, DPPH Assay, ABTS Assay, FRAP Assay.

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S. R. Pattan ¹, R. L. Hullolikar ¹, J. S. Pattan ², N. S. Dighe ¹, M. B. Hole ¹, S. H. Kale ¹, S. B. Bhawar ³

Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Department of Biotechnology, P V P Science College, Pravaranagar, Loni-413713, IN
3 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN

Abstract

Fifteen novel derivatives of phenyl thiazole derivatives were synthesized. The synthesized compounds were tested for their preliminary tests, physical constants, TLC, solubility, etc. the structures of the final compounds were confirmed by IR, ¹H-NMR Spectra and CHN analysis. The proposed compounds were screened for their antimicrobial, antifungal, activities with the standard drugs.

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R. Pattan Shashikant ¹, Kekare Prajact ², N. S. Dighe ¹, S. B. Bhawar ³, Nikalje Ana ⁴, Pati Ashwini ⁴, M. B. Hole ¹

Affiliations
1 Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, IN
2 Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum 590 010, IN
3 Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, IN
4 Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad, IN

Abstract

A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, ₁H-NMR and elemental analysis. All the compounds (B₁-B₉) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.

Keywords

Thiazolidinedione, Antidiabetic Activity, Microwave Assisted Synthesis.

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Nikhil Kute ¹, S. D. Mankar ¹, S. B. Bhawar ¹

Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, IN

Abstract

Biosimilars are biological products that are the replicas of their innovator biopharmaceuticals. The term “biosimilar” is in common use in the European Union, while the term “follow on biologics” is more popular in the American context. These are developed after patent expiration of innovator biopharmaceuticals and are submitted for separate marketing approval. In view of the structural and manufacturing complexities of biopharmaceuticals, biosimilars should not be considered as “biological generics”. These are rather unique molecules with limited data at time of approval, so there are concerns about the safety and efficacy of biosimilars. The Indian biotechnology industry is also gaining momentum, with revenues of over U.S. $ 2.0 billion in 2006, 70% of which is biopharmaceuticals. These are projected to reach up to $580 million in 2012.This article will address the differences between biosimilars and chemical generics, issues of concern with the use of biosimilars and need of appropriate regulations for their approval.

Keywords

Biosimilar, Chemical generic, Current status, Issues concern, FDA approach.

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Avesh Tamboli ¹, Priyanka Sadaphal ¹, S. D. Mankar ¹, S. B. Bhawar ¹

Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar (Loni BK), Ahmednagar, Maharashtra, 413736, IN

Abstract

Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or nonvasospastic angina secondary to a hypersensitivity reaction. It was first described by Kounis and Zavras in 1991 as the concurrence of an allergic response with an anaphylactic or anaphylactoid reaction and coronary artery spasm or even myocardial infarction. Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome. There are many triggering factors, including reactions to multiple medications, exposure to radiological contrast media, poison ivy, bee stings, shellfish, and coronary stents. In addition to coronary arterial involvement, Kounis syndrome comprises other arterial systems with similar physiologies, such as mesenteric and cerebral circulation resulting in ischemia / infraction of the vital organs. The Incidence of this condition is difficult to establish owing to the number of potential instigating factors and its relatively infrequent documentation in the literature. Anaphylaxis rarely manifests as a vasospastic acute coronary syndrome with or without the presence of underlying coronary artery disease. The variability in the underlying pathogenesis produces a wide clinical spectrum of this syndrome. Kounis syndrome is not just a single organ but also a complex multisystem and multiorgan arterial clinical conditions, it affects the coronary, mesenteric, and cerebral arteries and is accompanied by allergy hypersensitivity anaphylaxis involving Skin , respiratory system and vascular system in the context of anaesthesia, surgery, radiology ,oncology or even dental and psychiatric medicine , further it has significantly influences both morbidity and mortality. Kounis syndrome is caused by inflammatory mediators released during allergic insults, post inflammatory cell activation and interactions via multi directional stimuli. A platelet subset of 20% with high and low affinity IgE surface receptors is also involved in this process.

Keywords

Acute coronary syndrome, Mast cell, Histamine, Leukotriene, Kounis syndrome.

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